III2022-004
CELL GROWTH, DIFFERENTIATION AND ACTIVATION (CDAC)
Infectious, inflammatory and immune-mediated diseases area.
Objectives and lines of research
– Involvement of NOTCH4 receptor in differentiation and activation of tumor-associated macrophages.
– Involvement of Notch3 and Notch4 receptors in the alternative activation of macrophages in allergic inflammation.
– Study of NOTCH receptor function in highly aggressive human tumors using gamma-secretase complex (gsis) and alpha-secretase inhibitors adam 10 and adam 17.
– Studies of the sensitivity of meiotic recombination to diet-induced epigenetic changes in sperm that may affect the health of offspring.
– Involvement of Notch3 and Notch4 receptors in the alternative activation of macrophages in allergic inflammation.
– Study of NOTCH receptor function in highly aggressive human tumors using gamma-secretase complex (gsis) and alpha-secretase inhibitors adam 10 and adam 17.
– Studies of the sensitivity of meiotic recombination to diet-induced epigenetic changes in sperm that may affect the health of offspring.
Research team
- MARÍA JOSÉ MARTÍNEZ DÍAZ-GUERRA
- JOSÉ JAVIER GARCÍA RAMÍREZ
- VICTORIANO BALADRÓN GARCÍA
- ELENA DE LA CASA ESPERÓN
- MARÍA LUISA NUEDA SANZ
- EVA MARÍA MONSALVE ARGANDOÑA
- MARÍA JULIA GONZÁLEZ GÓMEZ
- FRANCISCO M. RUIZ
- NATALIA CAROLINA HERNÁNDEZ DE LEÓN DE CASTRO
- MARÍA JOSÉ ROMERO DE ÁVILA GARCÍA-UCEDA
- DAVID FERNÁNDEZ DÍAZ
IPs
MARÍA JOSÉ MARTÍNEZ DÍAZ-GUERRA
JOSÉ JAVIER GARCÍA RAMÍREZ
FINCA DE LA PERALEDA, S/N. 45071. Toledo
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