CRO2022-004

SURGERY, HOSPITAL GENERAL UNIVERSITARIO DE CIUDAD REAL

Area of chronic diseases and cancer

Objectives and lines of research

ONCOLOGY LINE
– Development of a program for the multidisciplinary treatment of colorectal liver metastases.
– Creation and development of a cytoreductive surgery program and intra-abdominal treatment with hyperthermic intra-abdominal chemotherapy for patients with peritoneal carcinomatosis of digestive and ovarian origin as a reference center in our community.
– Development of utility models for the development of chemohyperthermia in patients with peritoneal carcinomatosis of digestive and ovarian origin.
– Development of filter systems for the isolation and treatment of tumor stem cells in drug recirculation during chemohyperthermia.
– Comprehensive, bidirectional and individualized treatment program to improve the prognosis of advanced stage neoplasms.
– Creation and development of a murine peritoneal carcinomatosis model, with a pancreatic neoplastic cell line, for therapy by cytoreductive surgery together with closed intra-abdominal chemohyperthermia.
– Development of an individualized comprehensive therapy program in neoplastic patients with the use of “avatars” after tissue transplantation and isolated stem cells in pancreatic cancer.

DEVELOPMENT OF BIOACTIVE SUBSTANCES:
– Preclinical development of anti-inflammatory and antineoplastic functionality of new products of plant origin in collaboration with the uclm.
– Use of biocompatible pga materials for drug delivery in digestive neoplasms. onset in experimental models of pancreatic cancer.
– Development of systems with bioactive particles for the selective elimination of bilirubin in perioperative critically ill hemodialyzed patients. patent development, “biliaway”.

IMPLEMENTATION AND DEVELOPMENT OF NEW SURGICAL PATHWAYS:
– Development and implementation of a Cytoreductive Surgery+HIPEC program for ovarian, stomach, colon and pancreatic cancer.
– Initiation and development of a Hepatobiliopancreatic Surgery program with laparoscopic access (2009-2022). -Initiation and development of a hepatic selective monitoring program in a volumetric restriction model in liver surgery (2009-2022).
– Development of an autologous islet of Langerhans transplantation program for patients with pancreatic cancer after pancreatic resection.