– The Translational Research Group in Cellular Immunology (GITIC) focuses on the study of the antigen-specific cytotoxic T cell response depleted in chronic viral infections and cancer. This group has studied this type of response in chronic HBV, HCV, HIV and hepatocarcinoma infection.
– Currently, our group is interested in the characterization of the metabolic phenotype of the virus-specific CD8 progenitor population in HIV and HBV infection.
– In addition, we are interested in other translational aspects derived from the study of this response, such as defining a treatment stopping rule in chronic HBV hepatitis, based on the characteristics of the CD8+ HBV-specific response and serological biomarkers. We are also working on cellular markers that allow rapid differentiation between chronic HBV hepatitis and chronic HBV infection.
– Our group addresses issues of delayed diagnosis, missed opportunities, advanced HIV disease (CD4 lymphocytes < 200 cells/mcL), classical opportunistic infections and different antiretroviral treatments.
– The group also participates in various expert panels for the development of national clinical practice guidelines.

• JUAN RAMÓN LARRUBIA MARFIL
• MIGUEL TORRALBA GONZÁLEZ DE SUSO
• HENAR CALVO SÁNCHEZ
• JOAQUÍN MIQUEL PLAZA
• EDUARDO SANZ-DE-VILLALOBOS
• ALEJANDRO GONZÁLEZ-PRAETORIUS
• JULIA PEÑA ASENSIO
• JENIFFER DE LA CARIDAD MARTÍNEZ GONZÁLEZ
• ALBERTO DELGADO FERNÁNDEZ